IMMUNOLOGY 2025

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Theater Workshop

Sunday, May 4 @ 1:15 PM
(at the AAI main booth)

Echoes of Immunity Past: Decoding the Ubiquitous, Highly-individualized, and Surprisingly Stable World of Autoantibodies

Tyler Hulett, PhD - CSO, CDI Labs

There is no such thing as an immunologic twin: Despite identical genomes, monozygotic twins develop remarkably different antiviral and autoantibody profiles that remain stable for decades (HuProt Microarrays, VirScan PhIP-Seq, HuScan PhIP-Seq,).

Syngeneic mice contain diverse serum antibody profiles: Environmentally controlled inbred mice still develop distinctive individual autoantibody signatures, challenging the concept of biological replicates in preclinical research (HuProt Microarrays, MouseScan PhIP-Seq).

Disease signals stand out from individual noise: While the majority of autoantibodies remain unique to each individual regardless of health status, disease-associated signatures emerge in inflammatory bowel disease, Sjogren’s, dementia, and more (HuProt Microarrays, VirScan PhIP-Seq, HuScan PhIP-Seq).

Real impacts on your research: Autoantibody mechanisms likely affect your experimental outcomes, driving variability, treatment non-response, and adverse events. Learn to account for these differences or leverage them to uncover novel disease mechanisms hidden within this landscape of immune individuality.