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- 2024
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The World's Most Comprehensive Portfolio and Content for Autoantibody Detection and Target ID
Transformational products and services for proteome-wide autoantibody profiling, biomarker discovery, cross-reactivity screening, and other whole-proteome target identification and interaction assays
We Offer the Most Powerful Antigen Libraries
21,000+ Full-length Proteins
Correctly-folded, GST-purified recombinant proteins and isoform variants
All Human Proteome
Detects antibodies against 48,921 unique human proteins and protein isoforms
All Murine Proteome
Detects antibodies against 50,135 unique murine proteins and protein isoforms
VirScan®, HuScan® and MouseScan™ are provided exclusively by CDI Labs Canada.
PUBLICATION HIGHLIGHT
A causal link between autoantibodies and neurological symptoms in long COVID
AUTHORS
ABSTRACT
Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated autoantibodies have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified diverse AAB targets in LC patients that correlated with their symptoms. Elevated AABs to proteins in the nervous system were found in LC patients with neurocognitive and neurological symptoms. Purified Immunoglobulin G(IgG) samples from these individuals reacted with human pons tissue and were cross-reactive with mouse sciatic nerves, spinal cord, and meninges. Antibody reactivity to sciatic nerves and meninges correlated with patient-reported headache and disorientation. Passive transfer of IgG from patients to mice led to increased sensitivity and pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance and coordination, reflecting donor-reported dizziness. Our findings suggest that targeting AABs could benefit some LC patients.
More Content and Better Data
We start with sequence-confirmed plasmids, then individually express and GST-purify proteins from S. cerevisiae. Piezolelectric printing is used to spot these in duplicate alongside controls. Quality is confirmed with anti-GST QA/QC. Successful folding demonstrated by kinase autophosphorylation assay.
PUBLICATIONS
260+peer-reviewed publications
With over 260 publications (and growing), our antibody seromics solutions and HuProt array continue to play a key role in life sciences by contributing to critical studies that help accelerate research, advance discoveries, and translate discoveries to novel products that improve human health.
CUSTOMER-BASE
190+customer base
Our customer base continues to expand throughout North America, Europe, and Asia Pacific, and is a testament to the quality and consistency of our products and services.
FOUNDERS
Boeke, Zhu & Blackshawat Johns Hopkins University
Funded by NIH Common Fund Support for the Development of Protein Capture Reagents and Technologies, the HuProt Protein Microarray was created by CDI Labs co-founders Jef Boeke, Heng Zhu, Dan Eichinger, and Seth Blackshaw, faculty members at the High Throughput Biology (HIT) Center at the Johns Hopkins University School of Medicine.